How JustAnswer Works:
  • Ask an Expert
    Experts are full of valuable knowledge and are ready to help with any question. Credentials confirmed by a Fortune 500 verification firm.
  • Get a Professional Answer
    Via email, text message, or notification as you wait on our site.
    Ask follow up questions if you need to.
  • 100% Satisfaction Guarantee
    Rate the answer you receive.
Ask Dr Basu Your Own Question
Dr Basu
Dr Basu, Experienced Specialist
Category: Medical
Satisfied Customers: 28672
Experience:  MD
23744323
Type Your Medical Question Here...
Dr Basu is online now
A new question is answered every 9 seconds

How long do Saphris withdrawal symptoms last? I was originally

Resolved Question:

How long do Saphris withdrawal symptoms last?

I was originally placed on the drug as adjunctive therapy for treatment resistant depression (it didn't improve my symptoms). I've moved (new doctor) and no longer have depression symptoms, and have tried going off of the Saphris twice, but end up with severe insomnia and anxiety. I've gone for as long as 4 days without Saphris, and the insomnia continues until I resume the drug. I have never required treatment for anxiety (Xanax) other than when I have attempted to discontinue the Saphris. I currently take only 1.25mg (a quarter of a 5mg tablet) a night. I want off the drug but the withdrawal effects are miserable. I know the half-life is 24 hours, but I can't find any information on how long the withdrawal symptoms are likely to last. Any insight would be welcome.

Thanks.
Submitted: 5 years ago.
Category: Medical
Expert:  Dr Basu replied 5 years ago.

Mysticdoc :

The views expressed by me are for educational purposes only and do not establish a doctor patient relationship.

Mysticdoc :

Hello

Mysticdoc :

Thanks for your question.

Mysticdoc :

Asenapine is an atypical antipsychotic medication.

Mysticdoc :

It works by inhibiting the serotonin and dopamine system in the brain.

Mysticdoc :

The medication effect may remain for 3-4 days even after stopping it.

Mysticdoc :

The withdrawal symptoms can last for several days although data is lacking on exactly how long.

Mysticdoc :

Hence, if insomnia and anxiety are the main issues after stopping saphris or asenapine, then you can use natural supplements to minimize the symptoms.

Mysticdoc :

Asenapine is the active ingredient of Saphris.

Mysticdoc :

You can try Valerian root and melatonin to help with your withdrawal symptoms.

Mysticdoc :

Best wishes,

Mysticdoc :

Please click ACCEPT button and leave a POSITIVE FEEDBACK, if you do not have any further question, so that I get rewarded for my time & effort. Thank you!Please ask for Mysticdoc for your future questions. Please bookmark my profile for asking further questions!This is the link to my profile: http://www.justanswer.com/medical/expert-mysticdoc/

JACUSTOMER-3vj2x7qe- :

I tried melatonin (5mg) and zolpidem XR (12.5mg) the last time I tried to go off of Saphris and neither seemed to help with the insomnia.

Mysticdoc :

In that case, you need to try trazodone.

Mysticdoc :

Trazodone counteracts the effects of saphris.

Mysticdoc :

Trazodone 50 to 100 mg at bedtime should be helpful

Mysticdoc :

Best wishes,

JACUSTOMER-3vj2x7qe- :

Can trazodone be taken safely with Cymbalta? I'm on a 60mg dose of Cymbalta.

Mysticdoc :

No they interact with each other.

Mysticdoc :

In fact they potentiate each other's action.

Mysticdoc :

There are risks of more side effects.

Mysticdoc :

muscle rigidity, high body temperature, tremors are some of the side effects.

Mysticdoc :

The dose may need to be adjusted if you develop any side effects.

Mysticdoc :

Best wishes,

Mysticdoc :

Please click ACCEPT button and leave a POSITIVE FEEDBACK, if you

do not have any further question, so that I get rewarded for my

time & effort. Thank you!

Please ask for Mysticdoc for your future questions.

Please bookmark my profile for asking further questions!

This is the link to my profile:

http://www.justanswer.com/medical/expert-mysticdoc/

Dr Basu and 5 other Medical Specialists are ready to help you