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Thanks for the details. I would say that there are few important possibilities which should be investigated and these are kidney disease, liver disorder, nutritional deficiency, autoimmune disorder. I will advise to have these tests such as blood urea/creatinine, liver function tests, ANA levels, c-reactive protein, blood culture. I will suggest to see a specialist in internal medicine for complete evaluation and these tests. It is important to have early examination & tests done in order to rule out any thing serious. Best wishes.
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