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doctornihil, Board Certified Physician
Category: Medical
Satisfied Customers: 2350
Experience:  MD, MPH
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I have an elevated CRP and positive ANA. I have joint pain,

Resolved Question:

I have an elevated CRP and positive ANA. I have joint pain, fatigue, depression. How do I know if it is Lupus or RA. My sed rate is normal. My last stress test for heart was normal. I am 58 and female
Submitted: 6 years ago.
Category: Medical
Expert:  doctornihil replied 6 years ago.

doctornihil :


doctornihil :

Thankyou for your question.

doctornihil :

Can you please tell me when did you take this test, recently?

Dr. Haroon Iqbal :

Hi and welcome to justanswer!

Customer: replied 6 years ago.
Last saturday, but have had increased pain in joints and fatigue since the spring
Expert:  doctornihil replied 6 years ago.


welcome to JA.

positive ANA & CRP do suggest likelihood of inflammatory condition.

RA can be ruled out by sending out RA factor & anti CCp factor 9 blood tests) and laso by joint Xrays looking for characteristic changes.

Lupus has certain diagnostic criteria as per American Rheumatological Association.

based on that criteria, you are more likely to have Lupus.

it is better you see a rheumatologist for a detailed clinical evaluation, as diagnosis requires both clinical findinigs along with positive lab results.

Additional lupus labs like Anti ds DNA, Anti Smith antibodies should be sent out as well.


Customer: replied 6 years ago.
My CCP antibodies were elevated for IgG/IgA, RA factor was WNL. Sjogren's anti ss-a and b were normal. Copper is elevated. TSH is down to 1.270 but T4 is 8.1 I have no problems with rash on face. I am in the sun alot.
Expert:  doctornihil replied 6 years ago.

anti CCP is very specific for RA.

in that case this is likely RA.

ANA & CRP can be positive with RA as well.

RA factor has less sensitivity for RA diagnosis.


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