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This (65,000 platelet count) is low platelet level. Low platelet level carries increase risk of bleeding. Chronic hepatitis C can cause low platelet count through one or more of the following means: hepatitis C can destroy some of the liver structures and increase the pressure in the surrounding blood vessels, and spleen - with the net effect of some platelet destruction; hepatitis C can stimulate the autoimmune reaction to destroy platelets, and finally the hepatitis C virus can directly infect the platelets. Treatment of hepatitis C with alpha interferon can reduce the low platelet of hepatitis C. In general, normal Platelets count is between 200,000-400,000 count/ml of blood. If the platelet level goes lower than 50,000 platelets/ml, patient is at increased risk of bleeding with injury. When the platelat count goes further below 20,000 count/ml there is even greater risk for bleeding, and levels below 10,000 count/ml there is much risk for spontaneous bleeding which is life threatening.

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