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Decrease in the red blood cell count and hemoglobin is called anemia.
The yellowish discoloration of skin is jaundice.
Anemia along with jaundice occurs when the red blood cells are destroyed excessively and is called hemolytic anemia. Reticulocyte count may be done which will be increased if it is hemolytic anemia.
The causes of hemolytic anemia ( there are innumerable causes) can be of any of the following three categories -
1. Immune mediated -wherein the immune system destroys the red cells by forming antibodies. The inducing factor could be medications, malignancy, transfusion etc.
2. Microangiopathic- wherein the red cells are destroyed due to mechanical effects
In microangiopathic hemolytic anemia the red blood cells get damaged while they pass through small blood vessels whose inner lining is abnormal ( which mechanically destroys the red blood cells).