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The 9.1 uric is considered quite high and is associated with two metabolic problems;
2) formation of urate kidney stones
Two classes of drugs are available for use as urate-lowering agents. The first is xanthine oxidase inhibitors, which block metabolic steps in the synthetic pathway of uric acid. Drugs are allopurinol and febuxostat. The other class of drugs are uricosurics, such as probenecid, which act to increase renal (kidney) uric acid secretion. Other uricosurics medicines are sulfinpyrazone and benzbromarone.
In addition to the standard agents other drugs have been found to have salutary effects on serum uric acid. Vitamin C has shown to have a mild urate-lowering effect at a dose of 500 mg daily. Fenofibrate, losartan or amlodipine have been demonstrated to have mild uricosuric effects.
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The treatment reduces the blood levels of uric acid in around 72 hours or less in majority of people. The tiredness and cramps can be associated with the high uric acid. This continuous high level can precipitate the crystal in the joints and that destroys the synovium (joint covering), which can lead to long term pains, swelling and decreased range of movements.
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