Have Medical Questions? Ask a Doctor Online!
Generally if you are taking a short course of steroids, you wil not be more suseptible to infection.
Chronic steroids (like over three weeks in duration) certainly can increase your risk of infections.
But the ZPak is designed to give you essentially 10 days of antibiotic coverage (since the medication stays in your body long after you have actually finished the 5 days worth of pills) -- and so you should be OK.