Welcome to Just Answer.
Garageband isn't necessary for your Mac to run. However, there is one thing you can do first to clean up a lot of space. OS X includes language files that aren't needed if you only plan to use English. You can download a program called Monolingual that will remove these other language files. It is available at http://monolingual.sourceforge.net/.
Oooh, thanks. Do you think the language files alone will free up 53MB? Any other big useless file you can think of? And your saying it is safe to ignore the corruption warnings when deleting packaged applications that came with the OS if I have never used them?
Yep, you can just drag it to the trash. If you don't have the install disk, you may want to hold off on deleting it in case you ever end up wanting to use it.
Removing the extra languages should free up at least 200-300 MB.
Also, you can search for the largest files on your Mac by using the a utility called GrandPerspective to scan your hard drive. It's available at http://grandperspectiv.sourceforge.net/. This will allow you to find what files and folders are consuming most of your space.
Thanks Kirk...very helpful. I am happy to be accept #122. Thanks again!
If you have a lot of media files (pictures, movies, music, etc), that is probably what is consuming the most space.