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Since he and the girlfriend are legally adults over the age of 18, then they are responsible for their own actions if they are allowed to stay in the vacation home. The owners of the home are not responsible for any illegal acts or actions that another legal adult may commit or engage in while in or on the property. If he allows minors to consume alcohol on the premises, then he could potentially be held liable for this under a criminal prosecution, but this wouldn't affect the owners of the property unless they supplied someone under 21 with alcoholic beverages.
So yes, it would be a wise idea to either remove or lock up any alcoholic beverages if you are going to allow him to stay there so as to avoid any potential liability.
Once they turn 21, they can legally consume alcohol so there wouldn't be any need to remove or lock up alcohol as they are then responsible for their own actions regarding consumption and the owners can't be held liable for supplying an underage person with alcohol.