Hi Nick. My name is***** you for your question and the opportunity to assist.
How long ago did this start?
System Restore may get this working.
With the computer started up in Safe Mode hold down the Windows logo key (just to the left of the spacebar) and press R.
The Run box will open.
In the text box type: rstrui.exe and click OK.
When System Restore starts click Next.
Put a checkmark in the Show more restore points box (if available)
Select a restore date when the USB ports were working and click Next.
Click Finish and allow the restore to complete.
After the computer restarts check that the USB ports are now working.
Let me know the result please.
This will not affect your files or programs.