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DepoMedrol stays around 18 to 24 hours in the system.
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There are two types of injections:
1) Methylprednisolone acetate; this if given in high dose may stay in the body for 7 days. It is given intramuscular.
2) Methylprednisolone sodium succinate; this stays in the body for 18-24 hours as the oral medicine. This can be given intravenous or intramuscular.
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Yes, DepoMedrol injection 80 mg IM can stay for 7 days as it is oil based and releases slowly.
Please see the reference:
Please see the other part of the reference (relevant portion reproduced);
Methylprednisolone acetate: Usual dosing range, 10-80 mg IM every 1-2 weeks; as temporary substitute for PO, given in daily IM dose equal to daily PO dose; for prolonged effect, given in weekly IM dose equal to 7 times daily PO dose; unlike methylprednisolone sodium succinate, may not be given IV
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