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Similar products to oclacitinib (Apoquel) is given to humans (ruxolitinib and tofacitinib) with more in the pipeline.
Recommended dosage of oclacitinib for a 130 pound dog is 55 mg. Assuming your wife is about that weight, a dose of 16 mg isn't much. The only possible drug interaction I found between this drug and her usual drugs is between drugs like oclacitinib and venlafaxine which has the potential to cause an increased risk of bleeding for someone with kidney disease. Of course, oclacitinib has not been tested with other drugs in humans since it is only labeled for dogs who typically don't take venlafaxine. Still, at the dose she took and as a one-time occurrance, it is unlikely to cause any problems at all. Any side effect might be nausea within a few hours of taking it. She should make sure she stays well hydrated.
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