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This is Dr. David
I am sorry about your husband.
jadenu can cause injury to the kidneys which can cause edema
giving lasix can cause more strain on his kidneys which is not a good idea
he should go to the ER and get blood work to check on his kidneys and blood creatinine levels
I would not use any more lasix or spironaldactone until he gets blood work to check on his kidneys.
he can use regular blood draws in the future to help lower his blood iron levels
let me know if you have other questions.