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Thank you for your question, it is true that colon cancer is a large risk factor with people who have colonic polyps.. But as he has been taking a lot of pain killers so most likely cause in his case is gut ulceration due to pain killers.OTer causes like inflammatory bowel disease, infection in the gut can also cause such symptoms. If he has weight loss unintentional more than 3-5% over few months then he needs a gut endoscopy ASAP. Let me know if you have questions. I am assistant professor in medicine and can help you with further questions, thank you. Do rate as positive if no further questions.