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Hi there,This is Dr Basu, experienced Internal Medicine Specialist.I am here to address your concerns and provide great service.
You can take again as excedrine is taken every 6 to 8 hours.
However, if you do not see any improvement in 2-3 hours after second dose, you should go to the ER for further evaluation.
High blood pressure, intracranial bleeding, stroke are some of the possibilities of persistent headache.Best wishes,It was my pleasure to help you today.If I have answered all your questions, Please rate my response Excellent (click on the 5th star).Please bookmark my profile for asking further questions!This is the link to my profile:http://www.justanswer.com/medical/expert-mysticdoc/