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It is not safe to use Vyvanase with the drugs you are already taking.
Using Vyvanase with Wellbutrin can cause increased risk of seizures.Both these medicines cause an increased risk of seizures but using them together increases this risk manifold.
In fact you should not be using Wellbutrin with Lexapro also increases this risk and combination of these two should be avoided as well.Please discuss this possible side effect with the doctor who has prescribed these medicines to you.