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This is called as Aniscoria. This has varied causes from nothing significant to life threatening. With the changes in the eye and history of weakness in knees, I would like to rule out anything related to brain and the nerve which controls the pupil (occulomotor nerve). Glaucoma (where the eye ball pressure increases) can also cause this. Inflammation of the iris termed uveitis also is responsible for these findings. He should be examined as early as possible. He may consider going to either emergency room or urgent care clinic for the evaluation.
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Hope you husband is doing good.
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Hope your husband is doing good.
Let me know the diagnosis, if possible.
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