I am Dr. Arun and will be helping you today.
I am sorry that your question was unanswered for long.
A raised alkaline phosphatase (AP) can be due to diseases of;
3) Bile ducts
Serum AP levels can rise as a result of either;
1) intrahepatic (obstruction inside the liver) like; primary biliary cirrhosis, primary sclerosing cholangitis, etc.
2) or extrahepatic (obstruction outside the liver); choledocholithiases, biliary stricture, etc. biliary obstruction.
In addition to liver and bile duct disease, several additional factors can affect AP serum levels. They are;
1) High-fat food intake can increase AP levels by 30 U/L;
2) Rise in BMI / obesity can increase AP levels by 25%;
use can lead to 10% rise in AP levels;
4) Chronic kidney disease has also been reported to raise serum levels of the intestinal AP isoenzyme.
So it is suggested that if following are not done, should be done for you;
a) Hepatitis profile
b) Other liver function tests
c) CT scan and ultrasound of the abdomen
d) ERCP or MRCP.
e) Bone scan
Please feel free for your follow up questions.
I would be happy to assist you further, if you need any more information.
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