The investigations are corroborated and interpreted in the context of;
3) physical exam findings
4) other investigations.
So investigations are usually not important in isolation. These are collectively able to point towards a diagnosis or rule out anything going abnormal or serious.
When the body produces increased numbers of platelets, the size of the average platelet increases, MPV is used to look at platelet output by the bone marrow. It helps along with other measurements to assess between hyperdestructive thrombocytopenia (actual destruction of platelets "normally" produced by the bone marrow) as in idiopathic thrombocytopenia purpura v/s hypoproductive thrombocytopenia. It is also being looked at as an indice in heart disease and diabetes as a predictor of stroke. A mild raise of MPV may not be important clinically to diagnose a medical condition, especially if there are no other corroborative investigative findings. Established cardiovascular risk factors, such as smoking, hypertension, dyslipidemia, and diabetes, can influence MPV, depending on confounding factors. Low-grade inflammation is one such factor. Evidence, particularly derived from prospective studies and a meta-analysis, suggest a correlation between a significant increase in MPV and the risk of thrombosis. A mild increase in MPV may be without any serious cause.
Mean corpuscular volume (MCV) is the average volume of red cells.
The common causes of macrocytic anemia (increased MCV) are as follow
Vitamin B12 deficiency
Hemolytic anemia (red blood cell destroying due to some cause)
Low thyroid (Hypothyroidism)
Excessive alcohol intake
Red cell distribution width (RDW) is a parameter that measures variation in red blood cell size or red blood cell volume. since RDW is mathematically derived from MCV, it is therefore affected by the average RBC size (MCV). Elevated RDW helps provide a clue for a diagnosis of early nutritional deficiency such as iron, folate, or vitamin B12 deficiency as it becomes elevated earlier than other red blood cell parameters.`
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