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Polycythemia Vera does not have a cure. However, there are a few thing that can be done to reduce the symptoms including medications that lower the cell count be causing the marrow to produce less blood cells including hydroxyurea and interferon-alpha. Radiation will also help destroy excess cells. Aspirin can relieve bone pain and burning feelings in your hands or feet and also thins the blood so it reduces the risk of blood clots.
There are some experimental treatments but of course these are not yet FDA approved. This will be something you will want to discuss with your doctor to see if the benefits outweigh the risks. The treatments include taking low doses of selective serotonin reuptake inhibitors which are medications that are used normally for depression.