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No I do not think that your lower leg swelling or weakness is caused by the lisonopril.
It may be related to your high blood pressure however.
It could be due to weakness or insufficincy of your kidneys as one possibility.
It may mean that you need a diuretic in addition to the lisonopril or that you need to have your meds adjusted.
The lower leg swelling may be caused by kidney problems, heart problems or venous insufficiency (leaky valves of the deep veins of the legs) as the three most common reasons for this problem.
I would recommend that you work closely with your doctor to determine the cause of the swelling in your case. The necessary treatment will vary according to the cause.
If you have venous insufficiency as the cause then you would likley see the swelling get better overnight and worse during the day. It would tend to get worse the more that you stood. This type of swelling would benefit from raising your legs to the couch or ottoman and using compression stockings to the knees.
If due to the heart or kidneys then you would probably need a diuretic to help clear the swelling as at least part of your treatment plan.
I hope this information helps.
If you have further questions then let me know and I will be happy to get back with you.
If my answer has been helpful and to your satisfaction then please remember to press the "ACCEPT" button. Thank you and Best Regards,
Anthony bray MD