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Hello, there seems to be a lot that has already been done. A verified Mono infection to start which can prolong sickness over many months even with malaise and tiredness. She is taking a lot of medication, but the problem now seem more an irritant ona and itch, have you tried simple antihistamines for itch relief?
The only antihistamine I started using last night was Piriton ( Chlorpenarimine). She seems better today but from past experiences I had myself two years ago I took 2 tablets of Zrytec. Would that be helpful? Thanks!
It is well possible yes, hence she seems to be better off with an antihistamine and you have a better experience you may try that, but you should refer to a doctor if things do not pass
She can experience discomfort for a while but she is on a large cocktail of medications and not much more thyere should be added
Hope this helps and best of luck