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Ever since my battle with depression began 12 yrs ago, I have had a decreased sex drive but was still able to actually enjoy the act once it was started. I have been on Wellbutrin for ~8yrs, and was prescribed Abilify ~2 yrs ago to combat worsening symptoms. I was told it "boosts" the Wellbutrin, unfortunately I began having Parkinson-like symptoms so had to stop. Actually had an increase in sex drive while on Abilify! Happy husband! Next "booster" prescribed was Cymbalta, which completely deadened any sensation from the chest down. Stayed on that about a year, until husband asked me to please try to find a different med w/o that side effect. Next came the Pristiq, which I have taken for about a year....same issue as the Cymbalta. Have tried to get my psychiatrist, my primary doc, and two different ob docs to take my issue seriously but have basically been told it's better than suffering from depression and I will probably be on antidepressants the rest of my life.