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Valarie, Nurse (RN)
Category: Health
Satisfied Customers: 1228
Experience:  36+ yrs exprience medical, surgical, wound/skin care, nutrition, geriatrics, rehab, management
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Hello!I take a number of supplements to assist with muscle

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Hello! I take a number of supplements to assist with muscle inflammation and promote my health. As there are quite a few different supplements, I would like to check the following: - are there any unfavorable inter-reactions between any of these supplements? - are any of these supplements potentially harmful if used long-term? - are of the supplements counter-recommended if one has problems with pancreatic function (my family has a history of pancreatic problems, although I do not. However, I do not want to take any risks!)  
- Are there any side effects which I should be aware of (eg I read that R-lipoic acid can affect throid function).

I am a healthy 54 year old who does not smoke, takes regular exercise, is not overweight, and is not taking any medicine. The supplements are: - R-Lipoic acid - Acetyl-l-Carnitine - Ci-Q10 - N-acetyl-l-cysteine - Vitamins D3, C and a multi B-vitamin - A combined pill containing Gamma tocopherol, Vitamin K2, lycopene, lutein, selenium - Milk thistle - Omega 3 - Turmeric - Ginger - L-glutamine - Probiotics Many thanks for your help!
Hello. Thank you for coming to JustAnswer with your question, and welcome.

Before I answer your question, can you tell me if you have any health conditions you are aware of currently? And do you take any prescription medications?
Customer: replied 4 years ago.
Apart from various menopausal symptoms (mainly fatigue), I am in good health. I have a slightly swollen thyroid, but recent blood tests of T3/T4 levels have come back normal. I also have chronic shoulder problems, but it is more of an annoyance than a handicap. I have also had some diziness which my doctor thinks may be BPPV. I am not taking any prescription medications.
There are no listed interactions between the supplements you have listed. I am working on a list of adverse reactions now, it will be a little while before I have it completed.

Note: I will need to list both responses as an answer, but you can wait until I post the next answer before you decide to "accept".
Customer: replied 4 years ago.
Thank you Valerie. I look forward to your next reply about adverse reactions!
Lipoic acid: No adverse reactions have been reported in either animal or human studies, even with large doses or extended use. But, its use in diabetes may warrant a reduction in insulin or other oral diabetic medications. Close monitoring of blood sugar levels must be performed.

L-Carnitine: there are quite a few side effects that have been noted. Here is the short list:
High blood pressure, fast heartbeat, fever, abdominal or stomach cramps, diarrhea, headache, nausea or vomiting.
Less common Abdominal discomfort, body odor, depression, dizziness, impaired vision, loss of appetite or weight, swelling in hands, lower legs, and feet; tingling sensation, weakness.
And rarely: seizures.
Here is a link to the page for more details, as it is quite extensive:
You may want to consider not taking this. L-Carnitine is usually only prescribed for people with a deficiency. If you do not have a deficiency, you may overdose by taking the supplement. Most people get plenty of L-carnitine from the foods they eat. Highest sources would be red meat, ground beef, pork and dairy products.

Co Q-10:
Listed side effects are diarrhea; loss of appetite; nausea; stomach upset; trouble sleeping, as well as possible allergic reactions. There is no mention of long term effects most likely because it has not been studied well enough yet.

Glutamine side effects are listed as: chest pain;hearing problems; or signs of infection such as fever, chills, sore throat, flu symptoms, mouth sores, unusual weakness. nausea, vomiting, stomach pain, gas;
Less serious side effects may include:
nausea, vomiting, stomach pain, gas;dry mouth, runny nose; swelling in your hands or feet; muscle or joint pain, back pain; headache, dizziness, tired feeling; mild skin rash or itching; or increased sweating.

Milk thistle. Side effects are very rare, but might include upset stomach. Otherwise some people may have allergic reactions. There is nothing about long term use.

There is not much information about Lutein, and the information I did find did not list any side effects.

For the most part, the rest of the supplements listed are things that are currently recommended as supplements for immune system function and GI health. (antioxidants, probiotics, vit. D, probiotics) I have not come across anything about long or short term adverse reactions.

However, be aware that use of Vit E (tocopherols) and omega 3 fatty acids or fish oils can "thin" your blood, so you may bleed more easily. For this reason, I would not recommend taking aspirin on a routine basis unless prescribed by your doctor, who must be made aware of the supplements you are taking.

Also, if you do develop any health conditions that require treatment with prescription medications, you may need to have any interactions re-checked with these supplements.

The current thought about supplements is changing as time goes along. More and more, the recommendation is to get your needed nutrients from actual foods rather than supplements. I just need to make you aware of that. : ) Of course, you are final judge of what helps you feel and function optimally.
Valarie, Nurse (RN)
Category: Health
Satisfied Customers: 1228
Experience: 36+ yrs exprience medical, surgical, wound/skin care, nutrition, geriatrics, rehab, management
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