Thank you for the additional information. What did you mean though by "that one issue"? Are you saying the medications help but not for one body area?
I looked up the latest information on both chronic hives and angioedema.
The non-sedating antihistamines, such as you have been taking, are still the mainstay of treatment.
Another treatment which can be successful is a medication called Doxepin. It is in the tricyclic antidepressant class, but works on urticaria and angioedema by blocking H1 activity.
For angioedema, estrogen can be a factor that induces it in some cases, so if you happen to be on any birth control products containing estrogen, it might be beneficial to use a different form on a trial basis at least to see if that provides any relief.
There are other medications that can be used depending on the exact cause of your problem.
I have two medical articles that are written for Physicians and other Clinicians to guide them in treating patients with these problems. If you like I can provide you links to these articles - they may be somewhat complex but since you are affected you may like to study them yourself to further you knowledge over your condition. You could us ask any questions about them if you liked as well.
Let me know.