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Hello, Welcome to Just Answer and thanks for your question. There is no one specific thing indicated by high levels of eosinophils. Some things that can cause the elevation are allergies, drug reactions. blood disorders (hypereosinophilic syndrome, atheroembolic disease, tumor, leukemias, ,astocytosis, lymphomas), immunologic disorders (Hyper-IgE syndrome, thymomas, Ommen's syndrome), endocrine disorder (hyposarenalism), plus numerous skin (atopic dermatitis , bullous pemphigoid, pemphigus vulgaris, dermatitis herpetiformis, urticaria, eosinophilic panniculitis, angioedema with eosinophilia, Kimura's disease, Shulman's syndrome, Well's syndrome, eosinophilic pustular folliculitis), neurological, GI, pulmonary, cardiac, and kidney problems. It is a difficult problem to sort out.
It could be either epidermolysis bullosa (EB) or mastocytosis, but only biopsies will tell for sure. Sometimes that requires repeat biopsies. Both conditions fit the symptoms. As I noted, there are hundreds of things that can cause this problem, and figuring it out is a nightmare both for the providers and the parents.