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swelling of the legs could be from several causes including blood clot, varicose vein( incompetent valves )/ chronic venous stasis,kidney problems, heart problems , liver problems, infections and medicines, It is important to have ultrasound of the legs to rule out clot, cbc and BMP/ LFTS to evaluate liver and kidney. Echocardiogram for heart function. Usual medicines that can cause swelling in legs are aleeve/ ibuprofen, norvasc, rosiglitazone. A physical exam should be done to rule out infections.