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Welcome to Just Answer and thanks for your question. The amount to commit suicide would vary from person to person depending on weight, metabolism, other medications, how drug-naive they were, and many other factors. We are not in the business of furnishing suicide directions, so we won't even go there. You understand that these answers are not things we would want to be on the internet for others to read. The prescribing information for Effexor XR is below so you can learn as much as you care to about it. The most important thing is that you must take it exactly as directed.