The most likely thing I can think of is carpal tunnel syndrome. This typically causes pain, numbness and tingling on the thumb, pointer, middle, and part of the ring fingers. There is some thought that its from repetative movement (writing) but this is not completely known to be true yet. Other things that aggravate this is sleeping because people sleep with their wrist in aflexed position which irritates the nerve that is being pinched with this problem. You can avoid the repetative movements that aggravate the problem. You can also try picking up a wrist splint and wearing that at night. That can really help some people. If this is really carpal tunnel and the problem doesnt resolve with this conservative treatment you would likely benefit from surgery. Its fairly simple, pretty non-invasive, and effective for many people. Hope that helps.
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Not sure if you mean you wear the splint at night and the symptoms are still bothersome during the day. Or that once you have the symptoms during the day and apply the splint if doesnt help. Either way it seems as though this treatment hasnt been effective. Other things that can potentially help is to ice the wrist. Vitamin B6 helps some people although we dont know how. You can use NSAIDs to help with pain and inflammation (ibuprofen is one example of this medication). If these things dont work I would suggest a visit to the doctor to be evaluated for possible surgery. Hope this helps.