Welcome to Just Answer and thanks for your question. Cholesteatoma is a defect in the middle ear in which a growth exists. It will continue to grow unless removed surgically. It has the potential to cause conductive hearing loss, facial paralysis, brain abscess, and other serious complications. Since it is in the middle ear, there is no solution that can be induced into the ear canal that will reach it. Antibiotics are used in the ear to treat any infection that contributed to the formation of the cholesteatoma if it is from repeated ear infections rather than a congenital problem. Your otolaryngologist (ear, nose, throat doctor) would be the one to determine if this would be an option, or if the only treatment would be surgical.