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Dr. Arun Phophalia
Dr. Arun Phophalia, Doctor (MD)
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Experience:  MBBS, MS (General Surgery), Fellowship in Sports Medicine
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Can I take 600 mg of Zantac in one day Some websites say

Resolved Question:

Can I take 600 mg of Zantac in one day? Some websites say 300mg is the maximum and a few say you can take up to 600mg. I took 400 mg about 9 hours ago. I am in great of deal of pain. I can't sleep or eat. Also, can I cut the tablet in half? Is this a time-released medicine since the RX is for once a day, at bedtime? A hiatla hernis and acid reflux are the problem?
Submitted: 6 years ago.
Category: Health
Expert:  Dr. Arun Phophalia replied 6 years ago.

Greetings.

 

The usual prescription of the Zantac is 150 mg twice daily or 300 mg once a day. Taking more than these doses does not help either in the symtoms or control of the pathophysiological process. So further doses would not help you. Taking some antacid like Tums may help you in the pain.

 

Please feel free for your follow up questions.

 

Dr. Arun

Customer: replied 6 years ago.
<p>Why do some websites say you can take 400 mg or 600 mg then? Here is an excerpt from one of those websites: </p><li><a href="http://www.drugs.com/cons/zantac-150.html">http://www.drugs.com/cons/zantac-150.html</a> </li><li>To treat heartburn, acid indigestion, and sour stomach: <ul><li>Adults and teenagers-100 to 200 mg with water when symptoms start. The dose may be repeated once in twenty-four hours. Do not take more than 400 mg in twenty-four hours. </li><li>Children-Dose must be determined by your doctor. </li></ul></li><li>To prevent heartburn, acid indigestion, and sour stomach: <ul><li>Adults and teenagers-100 to 200 mg with water up to one hour before eating food or drinking beverages you expect to cause symptoms. Do not take more than 400 mg in twenty-four hours. </li><li>Children-Dose must be determined by your doctor. </li></ul></li><li>To treat conditions in which the stomach produces too much acid: <ul><li>Adults-300 mg four times a day, with meals and at bedtime. Your doctor may change the dose if needed. </li><li>Children-Dose must be determined by your doctor. </li></ul></li><li>To treat gastroesophageal reflux disease: <ul><li>Adults-800 to 1600 mg a day, divided into smaller doses. Treatment usually lasts for 12 weeks. </li><li>Children-Dose must be determined by your doctor</li></ul></li><p> </p>
Customer: replied 6 years ago.
<p>When can I tqke another one? Do I have to wait a full 24 hours?</p><p>Also why doesn't it help to take more?</p><p> Is it time-released? </p><p>Can I cut it in half and take sooner?</p>
What will happen if I take another 150mg after 12 hours?
Expert:  Dr. Arun Phophalia replied 6 years ago.

Hello,

 

Zantac is Ranitidine. The website gives information for the other medications also from the same family of the drugs like cimetidine and famotidine, which has different doses. Let me quote you the doses for ranitidine from the same resource (it is 150 and 300 mg);

 

http://www.drugs.com/cons/zantac-150.html

 

  • For ranitidine
  • For oral dosage forms (syrup, tablets, effervescent tablets):
    • To treat duodenal ulcers:
      • Older adults, adults, and teenagers-150 milligrams (mg) two times a day. Some people may take 300 mg once a day at bedtime.
      • Children-2 to 4 mg per kilogram (kg) (1 to 2 mg per pound) of body weight per day, usually given as two divided doses. However, your total dose will not be more than 300 mg a day.
    • To prevent duodenal ulcers:
      • Older adults, adults, and teenagers-150 mg at bedtime.
      • Children-Dose must be determined by your doctor.
    • To treat gastric ulcers:
      • Older adults, adults, and teenagers-150 mg two times a day.
      • Children-2 to 4 mg per kilogram (1 to 2 mg per pound) of body weight per day, usually given as two divided doses. However, your total dose will not be more than 300 mg a day.
    • To treat heartburn, acid indigestion, and sour stomach:
      • Adults and teenagers-150 mg with water when symptoms start. The dose may be repeated once in twenty-four hours. Do not take more than 300 mg in twenty-four hours.
      • Children-Dose must be determined by your doctor.
    • To prevent heartburn, acid indigestion, and sour stomach:
      • Adults and teenagers-150 mg with water taken thirty to sixty minutes before eating a meal or drinking beverages you expect to cause symptoms. Do not take more than 300 mg in twenty-four hours.
      • Children-Dose must be determined by your doctor.
    • To treat some conditions in which the stomach produces too much acid:
      • Older adults, adults, and teenagers-150 mg two times a day. Your doctor may change the dose if needed.
      • Children-Dose must be determined by your doctor.
    • To treat gastroesophageal reflux disease:
      • Older adults, adults, and teenagers-150 mg two times a day. Your dose may be increased if needed.
      • Children-5 to 10 mg per kg (2.3 to 4.6 mg per pound) of body weight a day, usually divided and given in two doses during the day. However, most children usually will not take more than 300 mg a day.
  • It can be cut in half and it is not time released. Ideally one should wait for 24 hours but if you take it 2-3 hours early with your symptoms, it does not harm you. It does not helps you in higher doses as optimal or plateau effect comes with the 300 mg doses and any increase in the doses does not document any change in the symptomatic effect or give more advantage by its mechanism of action. It is not like more you take, more you would be benefited.

     

    Hope this helps you.

     

    Dr. Arun

    Customer: replied 6 years ago.
    <li>Thank you for your reply....It does say for Ranititide the following as you indicated? So are you saying that it still won't help to take more (12 hours later)...below its says yoiur dose may be increased. What else besides antiacids will provide immediate relief...I don't have any antacids.</li><li>To treat <strong>gastroesophageal reflux disease</strong>: <ul><li>Older adults, adults, and teenagers-150 mg two times a day.<strong> Your dose may be increased if needed. </strong></li><li>Children-5 to 10 mg per kg (2.3 to 4.6 mg per pound) of body weight a day, usually divided and given in two doses during the day. However, most children usually will not take more than 300 mg a day. </li></ul></li>
    Expert:  Dr. Arun Phophalia replied 6 years ago.

    Hello,

     

    A definite treatment is antacids only to give you relief from pain. Eating fruits like banana may help. For immediate help there is nothing else as home remedy, I am afraid.

     

    Dr. Arun

    Customer: replied 6 years ago.
    <p>Thank you for your reply and patience. Sorry, but you didn't answer the first question re: the Ranititide. To quote from above, this says the dose may be increased if needed (from 150mg 2z a day)</p><p> </p><p>To treat gastroesophageal reflux disease: </p><ul><li>Older adults, adults, and teenagers-150 mg two times a day.<strong> Your dose may be increased if needed.</strong></li></ul><p><strong>Doesn't this indicate that you could take more....Are there any adverse effects if you do? Thanks. </strong></p>
    Expert:  Dr. Arun Phophalia replied 6 years ago.

    Hello,

     

    I am sorry for this. The dose may be increased of any medication by a physician's advice. The pharmacology advices or guide us (doctors) about the doses and we do make individual variations according to the built, body weight, response and other variables. Increasing the Zantac doses can be done in the individuals by the body weight issues and that is done for the long term, not for the episodic reason. Please remember, if one take Zantac now the optimal blood levels are built up in 5-6 hours. So, if at all the doses are increased, they are done to see the long term interest.

     

    No there are not big adverse reactions / untoward effects / side effects, but dose increase should be supervised by a doctor.

     

    You are welcome.

     

    It is pleasure assisting you.

     

    Dr. Arun

    Dr. Arun Phophalia, Doctor (MD)
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    Experience: MBBS, MS (General Surgery), Fellowship in Sports Medicine
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