Welcome to Just Answer and thanks for your question. The half-life of Lortab is just under 4 hours (the time it takes for half a dose to leave the body). It takes 6-7 half-lives for the drug to be completely gone, so one dose is gone in about 24-28 hours. If this is in reference to a drug test, then if hydrocodone is tested for, it will usually be found for 2-3 days after the last dose, assuming someone takes it on schedule. If you have a prescription for it, there is no problem. Drug tests are there to detect use of illegal drugs, not those prescribed by your health-care provider for legitimate needs.