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Your symptoms can be typical for sitting for a long period of time, especially on an airline flight or road trip. It is so important to stop, get up and move around to keep circulation to the legs moving well. Are you doing more walking at this time than you usually do. Leg cramping can be caused by low potassium (eat a small banana every day). low calcium level (ask the doctor if the level was checked and if you need a supplement), dehydration (drink plenty of water and low sugar drinks). Also, wherever you travelled to, was there any change in altitude, because high altitude can increase dehydration and create symptoms). You do not describe symptoms of having a blood clot. Concerning your family history of vascular disease, you can be evaluated by a vascular specialist, but I don't think it is necessary at this time unless symptoms worsen.