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Patty
Patty, Nurse Practitioner
Category: Health
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Experience:  RN 14 years, Masters in Nursing with specialization in Child and Adolescent Psychiatry
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does tegretol at 200mg b.i.d. affect the liver or serum ...

Customer Question

does tegretol at 200mg b.i.d. affect the liver or serum uric acid levels
Submitted: 6 years ago.
Category: Health
Expert:  Patty replied 6 years ago.

HiCustomer

Tegretol is a medication that is metabolized in the liver, depending on how your liver was functioning before you started taking the Tegretol. If you are having side effects from this medication, you may want to contact you doctor. You doctor can order a serum Tegretol level to see if your level is high. They can also check your liver enzymes and WBC count.

Tegretol is metabolized in the liver and also the kidneys. Are you having gout like symptoms? Increases in uric acid cause gout.

Here is a great website about the side effects and information about Tegretol.

http://www.drugs.com/pro/tegretol.html

I copied some of the info at the site for you regarding liver side effects

Tegretol is metabolized in the liver. Cytochrome P450 3A4 was identified as the major isoform responsible for the formation of carbamazepine-10,11-epoxide from Tegretol.

Hepatic effects, ranging from slight elevations in liver enzymes to rare cases of hepatic failure have been reported (see ADVERSE REACTIONS and PRECAUTIONS, Laboratory Tests). In some cases, hepatic effects may progress despite discontinuation of the drug.

Baseline and periodic evaluations of liver function, particularly in patients with a history of liver disease, must be performed during treatment with this drug since liver damage may occur (see PRECAUTIONS, General and ADVERSE REACTIONS). Carbamazepine should be discontinued, based on clinical judgment, if indicated by newly occurring or worsening clinical or laboratory evidence of liver dysfunction or hepatic damage, or in the case of active liver disease.

Genitourinary System: Urinary frequency, acute urinary retention, oliguria with elevated blood pressure, azotemia, renal failure, and impotence. Albuminuria, glycosuria, elevated BUN, and microscopic deposits in the urine have also been reported.

  • Lab tests, including complete blood cell counts, liver and kidney function, eye exams, and carbamazepine blood levels, may be performed while you use Tegretol . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Good luck, let me know if you have more questions.

    Patty

    Hope this helps, If you need anything else please feel free to ask. If you found this helpful don't forget to click the *ACCEPT* button and please take a moment to leave me *POSITIVE* feedback. A BONUS is always appreciated.

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