First of all, you sure lead a busy life. Are you busier than usual? Are you getting enough sleep, rest? Have you had a virus recently?
Depression, stress, anxiety will cause fatigue
Are you having heavy menstrual periods? You are at the age where you might be perimenopausal is the reason I am asking. If so, you might be anemic
My first thought is thyroid. Hypothyroidism is very common in women your age, and will cause that overwhelming fatigue.
Rapid weight loss might cause fatigue.
You may have a sleep disturbance, such as sleep apnea.
New onset of diabetes might cause the fatigue. Chronic fatigue syndrome.
You need to speak with your physician and rule out any medical reasons why this is happening now. And go over your lifestyle and personal issues. It might be you are just overwhelmed with stressors of life.
I wish I could give you the answer right off the top. Thyroid is my first guess. But you need to followup with your MD to get to the root of this.
I hope this was of help to you. Please let me know if you have any further questions or concerns.