Greetings,Customer Thank you for submitting your question(s) to JustAnswer.com in the category of HEALTH. My name isXXXXX I am a licensed physician, trained throughout Internship, Residency/Fellowship at the Mayo Clinic in Rochester, MN in the specialties of Internal Medicine and Critical Care.
Zoloft and alcohol are listed as two items to be avoided together because of CNS (central nervouse system) depression, meaning that they are concerned that your level of consciousness will be reduced dangerously low. As you know, these warnings are very often true, but also stated for reasons of liability for the manufacturer.
You have taken Zoloft for many years while ingesting a moderate alchohol intake. I know of no evidence listed for brain damage from Zoloft. We do know that alcohol is a nerve toxin when present in significant levels.
The toxic effects of alcohol on the brain, per se, are not intesified by Zoloft. In viewing the most recent literature of this issue, I just do not see this listed as a concern. The alcohol alone brings about concerns of neuron injury in the brain, but no additive effect of Zoloft to this process has been studied.
There is no long-term evidence of Zoloft damaging the brain or causing neuron injury. There is a suggestion that I can offer, however, if you truly wish to evaluate this process, realising that there is some degradation in cognitive thinking and processing possible with again alone.
You could take an extensive biobehavioural and cognitive series of tests, that can be arranged by your psychiatrist or healthcare provider. These testing series can be repeated at intervals to assess you for any cognitive decline or biobehavioural injuries or changes.
From a molecular biology standpoint, I cannot propose a mechanism of interactive brain cell (neuron) injury from the combination, but from the standpoint of alcohol as a neurotoxin itself, I can expect on at least some scale, perhaps small or large, there is neuron injury occurring.
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