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Mesenteric lymphadenitis refers to inflammation of the mesenteric lymph nodes. Non specific mesenteric adenitis is a self-limited inflammatory process that affects the mesenteric lymph nodes in the right lower quadrant. It is most frequently caused by viral pathogens, but other infectious agents have been implicated. If it is asymptomatic, usually no treatment is offered. An association with streptococcal infections of the upper respiratory tract, particularly the pharynx, has been documented in some studies.
It is usually a self-limited disease, and management is conservative. Radiologic intervention or further investigations are generally not indicated. Rotavirus and other viral vectors are the presumed cause in most cases. Although cultures can be taken of stool, most cases resolve without antibiotic treatment.