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I trust you are referring to Plendil.
On the average, it can take a week to two weeks for one's system to adjust to new medicine (may even take longer - depending upon the individual and type of medicine and condition) - but, with your condition, I wouldn't wait to find out, I would consult with your doctor as soon as possible, concerning this matter.
You may wish to review the following site that offers information about this drug.
Please take care. My prayers and thoughts are with you.
Peace, Love & Happiness,
The Mystic Wave