Welcome to Just Answer and thanks for your question. S-adenosylmethionine (SAM-e) is made in the body from two amino acids. As a supplement it is used for osteoarthritis and for improvement in mood, although there haven't been a lot of studies on how effective it is. The most common side effects are nausea and other digestive complaints. Other reported side effects are skin rash, dry mouth, bloody stool, thirst, increased urination, headache, hyperactivity, anxiety and insomnia.
It should not be used by someone who has Parkinson's, or by anyone under the care of a medical provider for depression, anxiety, bipolar disorder, or other mental illness.
ok well i have arthritis in my knee i thought it would help. do you suggest someone should not take this? what are your thoughts or recommendations?
If you aren't one of the patients for whom it is not advised (see above) then it may help, or it may not. In a couple of small studies it has been about as effective for osteoarthritis as over-the-counter anti-inflammatory medication (Advil, Motrin). You may not get any of the side effects. Taking it with food tends to minimize side effects.