Hi thank you for your question I will do my best to help.
Lets start with the codes.P0272 = cylinder #4 contribution/balance injector driver circuit operation faultP0226 = cylinder #2 contribution/balance injector driver circuit operation faultThese two codes are pointing #4 and #2 fuel injectors not contributing to the engine. (not delivering fuel as they should)In most cases this is telling you the injectors are bad. Replacing the injectors in most cases will fix the problem.But before we start replacing parts lets test to be cure.That may be why a misfire on the driver side. Cylinders #2 and #4 are the first two on that bank. A power balance test should be performed to confirm the cylinders missing.This is the Ford TSB article related to this problem.
This article supersedes TSB 08-16-9 to update the Part List.
Some 2003-2005 Excursion, 2003-2007 F-Super Duty and 2004-2008 E-Series vehicles equipped with a 6.0L engine may exhibit a misfire, lack of power, buck / jerk, excessive smoke or crank / no start. There are several potential causes for these symptoms.
Follow the Service Procedure steps to correct the condition.
If normal diagnostics lead to an injector concern, use the following diagnostics to confirm the cause of injector failure and / or to rule out other conditions which may cause the same symptoms as a failed injector.
Internal injector damage can be caused by lack of fuel system supply pressure. Restricted fuel filters and / or fuel line(s), or an inoperative fuel pump can create a low or negative fuel supply pressure. Low or negative pressures may hinder the return stroke of the injector intensifier plunger to its rest position, leading to internal injector damage. To diagnose for low or negative fuel pressure and to confirm if any injectors have been damaged:
Inert combustion gas in an injector can cause a random misfire in one or many cylinders. Combustion gas may leak past the injector's needle and seat, or the copper combustion seal. Once the combustion gas enters the fuel rail in the cylinder head, it then distributes to other injectors, typically on the same bank. To diagnose for combustion gas entering the fuel system:
Erratic supply of high pressure oil to injectors may cause a rough running engine. High pressure oil flow can be disrupted by faulty check valve(s) or a faulty injection pressure regulator (IPR) valve.
To diagnose, first perform a slow neutral run up in park / neutral. If the engine runs rough between 1200 and 2300 RPM proceed to Check Valve Diagnosis; if the engine runs rough between 3000 and 4000 RPM, perform PC/ED pinpoint test Q, if the engine continues to run rough between 3000 and 4000 RPM after having validated the ICP sensor and connector, then replace the IPR valve.
This is a lot to look over so please look it over and let me know if you need more help..