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Just based on this one code there is a few more diagnostics which need to be performed. Your concern does fit that of a coil or plug needing to be replaced but the fact the random misfire code came up this means that its a misfire on multiple cylinders, so its not just one coil or plug. If your at or near the 100k tuneup like above 70k I recommend all new motorcraft spark plugs to start. if it continues then you need to use a scan tool and watch the camshaft and crankshaft speed sensors to see if they show a glitch causing these misfires. next you need to monitor the fuel pressure. Then you would need to check for a dirty MAF sensor or clogged EGR valve.
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