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I am sorry to hear this is happening, but if she has legal guardianship this is a HUGE problem, because there are only two ways to resolve the issue. First, you need to go to court, with an attorney (that would be mandatory in a case like this) and you need to prove she is not acting in his best interests and needs to be removed as guardian. Not acting in his best interests means perhaps self dealing taking property for herself or it could mean not properly caring for him physically, mentally or even emotionally by denying him contact with the children.
Second, if she is committing any type of physical abuse or financial abuse, then adult protection services would get involved and can investigate and pursue her and remove her as guardian.
You can find a local elder law attorney in the area and you can do so at the same sites used by other attorneys, http://www.hg.org or http://www.lexmundi.com
I am afraid those are really your only options based on what you have stated.