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Is the problem in one eye or both eyes?Was your niece born premature?
The problem is in the right eye only and she was born at 41 weeks
Was that eye normal at birth?
Mom says the eye appeared slightly more green while the other was blue at birth but the size discrepency was not there until about 4 weeks of age
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I don't believe this eye problem is due to any developmental delay.
Most causes of retinal detachment in babies are due to prematurity. But with her born at 41 weeks, this is less likely.
Other causes of retinal detachment could be due to tumors in the eye or infections in the eye.
An ultrasound of the eye may be helpful in this situation.