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Please allow me to ask a few questions to better understand what may be happening with your husband.
Has his vision changed significantly?
Is he having any other side effects, like dizziness, chest pain, or shortness of breath?
I'm assuming this is topical Minoxidil 5% used for hair re-growth. I'm also assuming that this exposure was a small amount and not an entire bottle exposed to the eye. If these assumptions are wrong, please inform me.
In this case, what should be the two primary concerns are his systemic symptoms and his vision.
Minoxidil causes a sympathetic nervous system ("fight or flight") to occur in the body and so topically, in the eye, it will cause the pupils to dilate. Significant pain and significant vision changes should prompt a visit to the ER today, or to his ophthalmologist if he/she is available. In the absence of this, copious irrigation to the eye with water should continue--you can't do it too much.
If after irrigating for 15-30 minutes if he still has no significant eye pain, vision problems or areas of obvious visual concern for damage to the eye, waiting until tomorrow to see his ophthalmologist is a reasonable thing to consider.
Because this drug has powerful systemic effects, if he experiences chest pain, shortness of breath, dizziness, or loss of consciousness, he should be seen at the ER immediately (this is likely a no-brainer to you, but bears stating).
Does this address your concerns?
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Disclaimer: My opinion is solely informative and does not constitute an informed medical opinion or recommendation. For an informed medical opinion and/or recommendation you must see an eye doctor.
The Naphazolin HCL and Phenirmaine maleate solution will likely not have a significant negative or positive interaction in this case. I do not expect that it will help to any significant degree, nor do I expect that there will be a significant interaction between that and the Minoxidil.
As far as his internist's comments are concerned, waiting it out until tomorrow is a reasonable thing to consider. I would not necessarily recommend Benadryl to take for this because Benadryl is for allergic reactions and elicits somewhat of the same response in the body as the Minoxidil has already elicited. I think it would be counterproductive to use it.
Does this address the concerns you have?