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It is not uncommon to stay on eventually remain 1 pill per week for a very prolonged period (including life time) in order to keep the Lupus quiet and controlled. The enlarged red blood cells is likely due to anemia caused by a combination of folic acid
and Vitamin B12 deficiency. However, since you are taking the supplements of these vitamins, it is likely that the higher dose of methotrexate contributed to the anemia - as methotrexate tend to deplete the body of folic acid. Now that your of methotrexate is decreasing and you are on folic acid supplement, I would expect that the anemia would be better corrected. The methotrexate is also known to cause low potassium, so your low potassium level is likely caused by the high dose of methotrexate. However, the level will normalize with reduced dose. In the meantime, I suggest that you continue to follow-up with your doctor for closer evaluation and possible potassium supplement. Your uveitis
is related to the Lupus, and you should continue the FML drops to quiet eye inflammation and Alphagan to control your eye pressure.
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