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Legally speaking there is nothing improper about assigning a nurse to a hospital where they have not received orientation. It may not be "right" in the sense that it is poor management, but it is not against the law and the nurse could be lawfully disciplined or even terminated for refusing to work on this basis.
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Unfortunately, being uncomfortable would not be enough. There would need to be some reason that directly put patients at risk. Lack of orientation will never rise to that level because by this logic a nurse could refuse to work at any hospital other than the one they started at. It will always take some time to learn new hospital layouts. I have a lot of experience with employment law in the context of nursing and hospitals and I have never heard of a nurse successfully refusing an assignment on this basis. Attempting to do so would be to put your job at risk, I'm afraid.