Well, if they can prove misconduct related to the job, then you would be denied the unemployment, so you would have to prove there was no misconduct or you were never informed of the rules that you were accused of violating. As far as your weight, since you would likely be considered morbidly obese and I am sure it impairs a major life function, you could possibly be covered under the Americans with Disabilities Act and you could allege you were terminated based upon your disability. I would suggest you not only get an attorney to fight the unemployment appeal, since if you are successful there is a good chance that they will award you attorneys fees as part of your award, but you should also file a complaint with the state commission on human/civil rights and the EEOC for discrimination under the ADA.

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