Hello. My name is***** can help you with your question.
You can replace a Bose hard drive as long as you set up exactly the same as the original hard drive is set up. The Bose hard drive is formatted as two fat 32 partitions.
The size of the first volume is 29958 MB, and the second volume 8197 MB. The first volume is set as ACTIVE.
There are 3 folders that MUST be present (DATA, db and MUSIC).
You could try connecting the bose hard drive to a PC, and it should read the FAT32, but I don't think that the music will be in a format that is playable by a generic media player. The only way to know for sure would be to connect it to the computer.