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Hello! I hope I can help you. I would say that you have been overwhelmed by negatives in life. This female has been your one safe place. That has changed now and she has become part of the problem. Either her husband has become involved or your wife.
I would take the dream as a warning. You are obviously running from some negatives in your life. in the past you have found comfort in this friend. You may be tempted to turn to her again. The end of another encounter with her could be devastating. the one other interpretation could be similarly you deep down fear she may throw you under the bus and fess up bringing you down with her.