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Hi this is Dr. Hill. There is no legal reason why you cannot switch Frisky over to the compounded version. How it is compounded may make a mild difference in response. The only way to know is to do a trial with the compounded medication in the same concentration as the opt immune. Many dogs do well with the compounded generic. Please ask any follow up questions. You can continue posting on this thread for several days, even after rating my response. Take care.